He started his acting career at the age of five in several theater, film and television series.

[citation needed] He made his film debut in a minor role for Under Fire.

[citation needed] On television, he acted on three telenovelas with Televisa, before starring in Háblame de amor ("Talk to me about love").

In 1999, he produced and starred in Benjamin Cann's A Breakfast Chronicle, in which he was nominated for the Ariel Award for Best Actor.

[citation needed] Bichir made a 2018 guest appearance on the DC Universe series Titans as the first actor to portray Doom Patrol leader the Chief in live-action, although the role was recast with Timothy Dalton in the Doom Patrol's eponymous series.