After scoring in a regular basis for the youth sides,[1] he made his first team – and Série A – debut at the age of 16 on 22 May 2005, coming on as a second-half substitute for China in a 1–0 away defeat to São Caetano.

[2] After five first team appearances in 2005, Bruno Mezenga returned to the under-20s for the 2006 Copa São Paulo de Futebol Júnior.

[9] On 22 June 2011, Bruno Mezenga switched teams and countries again, after joining Serbian side Red Star Belgrade for a season-long loan deal.

On 3 January 2012, Bruno Mezenga rejoined Orduspor on a free transfer, signing a four-and-a-half-year contract with the club now in the Süper Lig.

[11] Despite scoring six times in the Spor Toto Cup as his side finished second, he failed to found the net in his nine league matches of the season.

[13] After scoring 17 league goals in his first season as the club narrowly missed out promotion, he added a further eight in his second, but the side only managed to avoid relegation.

[19] A backup option to starters Nicolas and Alef Manga, he scored four goals as the club achieved promotion to the top tier.

On 12 April 2023, Bruno Mezenga moved to top tier side Santos on loan until the end of the year.

Bruno Mezenga scored his first goal for Peixe on 31 May 2023, netting a late equalizer in a 1–1 away draw against Bahia, for the year's Copa do Brasil, but missed the decisive penalty as his club was eliminated 4–3 in the shoot-out.