[2] He made his professional debut in 2014 with the Dominican Summer League Astros, going 0–2 (win–loss record, W–L) with a 6.55 earned run average over 22 relief innings pitched.

[5] In 2019, he began the year with the Fayetteville Woodpeckers before being promoted to the Corpus Christi Hooks, with whom he was named a Texas League All-Star.

[13] In a three-game sweep of the Mariners in the 2022 American League Division Series (ALDS), Abreu appeared in each game, delivering 3+1⁄3 shutout innings, allowing two total baserunners, and striking out six.

[14] In Game 4 of the 2022 World Series, Abreu struck out the side in the seventh inning of a 5–0 combined no-hitter of the Philadelphia Phillies.

It was the third no-hitter in major league postseason history, and the second in World Series play, following Don Larsen's perfect game in 1956.

[18] Abreu led MLB in holds with 38,[19] and was second in the American League (AL) in pitching appearances with 78, a career high.