He split the 2012 season between the rookie ball AZL Padres and the Low-A Eugene Emeralds, accumulating a 6.46 ERA in 13 appearances.

In 2013, Rodriguez spent the year in Single-A with the Fort Wayne TinCaps, pitching to a 2-8 record and 3.19 ERA in 19 games.

He split the 2015 season between the Double-A San Antonio Missions and the Triple-A El Paso Chihuahuas, posting a 7-16 record and 4.88 ERA in 145.2 innings pitched.

Rodriguez again played for El Paso and San Antonio in 2017, registering an 8-8 record and 4.76 ERA with 68 strikeouts.

On October 15, 2024, the Fighters announced they would not be offering Rodriguez a contract for the 2025 season, making him a free agent.