[2] DePaula spent 2004 with the Single–A Quad Cities River Bandits, compiling a 12–7 record and 3.05 ERA with 88 strikeouts and 9 saves across 49 appearances.

[5] On October 18, 2006, the Twins added DePaula to their 40-man roster to prevent him from reaching minor league free agency.

[11] On January 6, 2009, DePaula signed a minor league contract with the Tampa Bay Rays organization.

He received an invitation to major league spring training, but did not make the club and was assigned to the Triple–A Durham Bulls.

[15] On August 21, 2011, DePaula signed with the St. Paul Saints of the American Association of Independent Professional Baseball.

On February 13, 2012, DePaula signed with the Rojos del Águila de Veracruz of the Mexican League.

On June 29, 2012, DePaula signed wi the Bridgeport Bluefish of the Atlantic League of Professional Baseball.

[20] In 2014, DePaula made 28 appearances out of the bullpen, compiling a 3–2 record and 2.48 ERA with 30 strikeouts across 29 innings of work.

[23] DePaula did not appear in a game for the Orioles, and was designated for assignment following the activation of Bud Norris the following day.

On May 1, 2015, DePaula signed with the York Revolution of the Atlantic League of Professional Baseball, marking his second stint with the team.

On May 21, 2015, DePaula signed with the Toros de Tijuana of the Mexican League, but was released two days later without appearing for the team.

Following his release from Aguascalientes, DePaula signed with the York Revolution of the Atlantic League of Professional Baseball for his third stint with the club.