Bryan L. Roth is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, UNC School of Medicine.
[1] He is recognized for his discoveries and inventions in the general areas of molecular pharmacology, GPCR structure, and function and synthetic neurobiology.
After postdoctoral training at the National Institute of Mental Health (NIMH), he completed a psychiatry residency and fellowship at Stanford University in 1991.
In 2003 he became a Professor of Biochemistry at Case Western Reserve University School of Medicine with secondary appointments in Psychiatry, Oncology, and Neurosciences.
[4][5] Other major works include identification of new probes and tools to detect GPCRs, obtained through directed evolution in animal cells,[6] developing receptors activated solely by a synthetic ligand (DREADDs), a chemogenetic platform used to direct selective, dose-dependent activation of a specific G protein subtype in vivo.