Bryse Wilson was born on December 20, 1997, in Durham, North Carolina, to parents Chad and Tracey.

[4][5][6] Wilson attended Orange High School in Hillsborough, North Carolina and played both baseball and football.

[10] Wilson made his professional debut with the Gulf Coast Braves in 2016, going 1–1 with an 0.68 ERA in 26.2 innings pitched.

On July 30, 2021, Wilson was traded to the Pittsburgh Pirates along with Ricky DeVito in exchange for Richard Rodríguez.

Wilson made 25 appearances (20 starts) for Pittsburgh in 2022, compiling a 3–9 record and 5.52 ERA with 79 strikeouts across 115+2⁄3 innings pitched.

Wilson made 34 appearances for Milwaukee in 2024, registering a 5–4 record and 4.04 ERA with 82 strikeouts over 104+2⁄3 innings pitched.

On November 4, Wilson was removed from the 40–man roster and sent outright to the Triple–A Nashville Sounds, but he rejected the assignment and elected free agency.