As a sophomore in 2018, he started all 59 games, hitting .365/.442/.556 with four home runs, 32 RBI and an NCAA leading 30 doubles.

[4][5] After the season, he played for the Wareham Gatemen of the Cape Cod Baseball League[6] and the United States collegiate national team.

[9] Bryson Stott also played summer collegiate baseball with the Wisconsin Rapids Rafters of the Northwoods League in 2017.

[20] He earned promotions to the Reading Fightin Phils of the Double-A Northeast and the Lehigh Valley IronPigs of the Triple-A East during the season.

[23] After impressing manager Joe Girardi during spring training, Stott was named to the Phillies' Opening Day roster for the 2022 season.

[24] He made his major league debut on April 8, 2022, recording a single, a double, and an RBI in the Phillies' 9–5 victory over the Oakland Athletics.

His first-inning leadoff single to center field off Lance Lynn in a 7–4 win over the Chicago White Sox in the first game of a doubleheader at Guaranteed Rate Field on April 18 set a new Phillies record, surpassing the 16-game hit streak established in 1950 by Willie "Puddin' Head" Jones.