[5][6] In May 2007, the institute established a cooperative agreement with the University of California's Davis and Merced campuses to coordinate stem-cell research.

[8] When Beryl Buck died in 1975, the bulk of the estate became part of the San Francisco Foundation, about $7.6 million dedicated to "charitable purposes in Marin County" including, "extending help to the problems of aging."

[8][10] As part of a 1986 court settlement, the Marin Community Foundation was established to administer the trust, valued in 2013 at approximately $1 billion.

[13] In December 2022, the institute hosted The Longevity Summit, a two-day conference on ageing, the emerging new biotech companies in the field, and their innovations.

[14] The institute is on a 488-acre (1.97 km2; 0.76 sq mi) site located in the foothills of Mount Burdell, north of Novato, California.

[13] It was leasing 27,000 sq ft of its campus to for-profit businesses, including BioMarin, Ultragenyx, Cellular Dynamics, An2H Discovery Limited, and Excel Venture Management.

[13] In 2015, California researchers opened the world's largest publicly available stem cell bank, with samples stored at the Buck Institute.

[23] In 2016, the institute launched a startup, called Unity Biotechnology First Company, aimed at developing medicines to treat age-related diseases and boost healthy lifespans.