Buffalo is a census-designated place (CDP) in Union County, South Carolina, United States.

The community was named for a nearby mineral lick which attracted buffalo.

[7] According to the United States Census Bureau, the CDP has a total area of 4.0 square miles (10 km2), all of it land.

There were 659 housing units at an average density of 164.2 per square mile (63.4/km2).

27.6% of all households were made up of individuals, and 11.2% had someone living alone who was 65 years of age or older.