Carlisle is a town in Union County, South Carolina, United States.

[5] Hillside and Woodland Plantation are listed on the National Register of Historic Places.

[7] According to the United States Census Bureau, the town has a total area of 1.4 square miles (3.6 km2), all of it land.

There were 223 housing units at an average density of 157.4 per square mile (60.8/km2).

30.7% of all households were made up of individuals, and 12.7% had someone living alone who was 65 years of age or older.