Cross Keys is an unincorporated community in Union County, South Carolina, United States.
[1] Historically, it was the site of the "large and prosperous" Cross Keys plantation.
[2] A post office was established at Cross Keys in 1809 and operated until 1909.
According to local history, Cross Keys was named following the travels of two British brothers from Charleston into the Upstate of South Carolina.
One brother, who had been in charge of sailing their ship, came across an area of land in southern Spartanburg County which he decided to settle, thus creating the community of Cross Anchor.