It was previewed at the 2006 North American International Auto Show,[1] officially as a concept car, making it the first Lambda vehicle to be displayed.

For its first year of production, the Enclave was powered by a 275-horsepower (205 kW; 279 PS) 3.6 L High Feature V6 engine mated to a six-speed automatic transmission.

Initial sales of the Enclave far exceeded production capacity, forcing GM to add a third shift to the Delta Township plant.

[8] Interior updates include a redesigned dashboard with more soft-touch materials, wood and chrome accents, blue ambient lighting, and touchscreen IntelliLink infotainment display.

[14][15][16] The long-wheelbase version of GM's C1XX chassis sharing the same platform with the Chevrolet Traverse, the second generation Enclave moved away from the egg-shaped design but retains some elements of the previous generation, displaying a sleeker aerodynamic appearance, a lower roofline, and the introduction of the Evonik Acrylite exterior forward lighting flanking Buick's new three-dimensional mesh grille with chrome wings.

The second generation Enclave comes standard in front-wheel drive or available with Intelligent AWD with an active twin-clutch rear differential, which complements its first switchable all-wheel-drive system.

[18][19] The mid-cycle refresh adopts many design elements and features along with new LED headlights and taillights already seen on the Chinese version of the Buick Enclave.

Buick planned to name the Chinese version "Envoy" (a name previously used on a GMC midsize SUV in North America from 1998 to 2007) but elected to use the Enclave name instead.

[24] General Motors unveiled the third generation Enclave on 9 April 2024, it will be available in three trim levels: Preferred, Sport Touring and Avenir.

[26] The interior has a floating center console with an ultra-wide 30-inch display for both the instrument cluster and touchscreen infotainment system - the largest screen in its class.

[26] All Enclave trim levels are powered by a turbocharged 2.5L inline-four gasoline engine producing 328 hp (245 kW) and 326 lb⋅ft (442 N⋅m) of torque paired to a 8-speed automatic transmission.