Burdock is an uninhabited ghost town in Argentine Township in Fall River County, South Dakota, United States.

In the county's square mile designation, Burdock is closest to 103rd Avenue and 273rd Street.

Burdock's nearest neighbors are Dewey to the northwest and Edgemont to the southeast.

The ghost town lies just to the southwest of the Elk Mountains, a small range that is part of the Black Hills.

In early 2012, Powertech (USA) Inc. (now called Azarga Uranium Corp.) submitted a proposal to the U.S. Bureau of Land Management to begin mining again.