[1] Studies in animal models suggest that butylphthalide may be useful for the treatment of hypertension[2][3] and may have neuroprotective effects.
[4][5][6][7] In 2002, NBP was approved in China for the treatment of cerebral ischemia.
[8] NBP undergoes extensive metabolism in humans.
Minor side effects were observed in preclinical and clinical studies.
The minor bioactivation pathway of NBP was proved to be mediated via sulfation of 3-OH-NBP.