[1] Studies in animal models suggest that butylphthalide may be useful for the treatment of hypertension[2][3] and may have neuroprotective effects.

[4][5][6][7] In 2002, NBP was approved in China for the treatment of cerebral ischemia.

[8] NBP undergoes extensive metabolism in humans.

Minor side effects were observed in preclinical and clinical studies.

The minor bioactivation pathway of NBP was proved to be mediated via sulfation of 3-OH-NBP.