[1] The hospital is located in the town of Bwera, in Kasese District, near the international border with DR Congo, approximately 132 kilometres (82 mi) southwest of Fort Portal Regional Referral Hospital.

[2] This is about 167 kilometres (104 mi) northwest of Mbarara Regional Referral Hospital.

It serves the surrounding sub-counties in Kasese District, and patients from neighboring Democratic Republic of the Congo.

[6] Like most government hospitals in the country,[7] Bwera General Hospital faces many challenges including non-functioning equipment,[8] under-staffing, poor funding, over-worked staff[1] and slow payment of staff.

[9] The hospital has an Ebola treatment unit which treated patients in June 2019 during the 2018–20 Kivu Ebola epidemic affecting neighbouring Democratic Republic of Congo.