[1] Winifred Kiiza was born on 26 November 1972, in Nsenyi Village, Kisinga sub-county, Kasese District, in the Western Region of Uganda.

Kiiza's father died when she was ten years old, leaving her care and that of her siblings in the hands of a single unemployed mother.

[1] She contested the Kasese District Women's parliamentary seat in 2006, on the opposition Forum for Democratic Change (FDC) political party ticket.

[1] In May 2016, Kiiza, at age 44, was appointed Leader of Opposition in the parliament of Uganda, making her the first woman to assume that position in the history of the country.

On 16 July 2020, she announced that she would not seek to become a Member of the Ugandan parliament again ending her 15 year reign as the Kasese District Woman MP even though she was still popular.