[1] The hospital is located in the community of Kilembe, on the campus of Kilembe Mines, in Kasese District, about 86 kilometres (53 mi) southwest of Fort Portal Regional Referral Hospital.

[2] This is approximately 166 kilometres (103 mi) northwest of Mbarara Regional Referral Hospital.

[3] The coordinates of Kilembe Mines Hospital are:0°12'14.0"N, 30°00'37.0"E (Latitude:0.203885; Longitude:30.010271).

[5][6][7] The hospital was established in 1951 to serve the staff of Kilembe Mines.

The three major benefactors of Kilembe Mines Hospital are (a) the Government of Uganda (b) Kilembe Mines Limited and (c) the Roman Catholic Diocese of Kasese.