It was the longest north-south line in the borough at the time, running nearly 8.4 miles (13.5 km), ending near the borders of Harlem in Manhattan and Mount Vernon in Westchester County until its current configuration in 2010.

Heading northbound, buses turn left onto Third Avenue to pick up passengers before heading north to East 152nd Street, where it turns left to continue north via Melrose Avenue.

[3] Shortly after, the MTA announced a proposed revision in the route's terminal loop at East 241st Street and Baychester Avenue.

[4] In March 2002, a plan to revise service on the Bx1, Bx2, and Bx41 routes in Mott Haven by extending the Bx1 and Bx2 to a new terminal at Lincoln Avenue and East 138th Street and truncating the Bx41 to East 149th Street and Third Avenue was announced.

The changes were intended to improve service reliability on the Bx1 and Bx2 by consolidating route supervision at their new terminal.

The truncation of the Bx41 made the changes cost-neutral and ensured there would not be too many buses in the vicinity of East 138th Street and Lincoln Avenue.

On August 16, 2008, Bx41 service were rerouted in The Hub due to the reconstruction of streets by the New York City Department of Transportation to improve pedestrian safety.

This would replace the Bx41 limited south of Fordham Plaza, as well as supplement the M60 bus in Queens.

[8] Many airport riders use the M60 and transfer in Harlem to the subway for service in the Bronx, and the Bx50 was proposed to relieve congestion from the M60.

The plan was pushed back in June 2010 due to budget cuts and was proposed again shortly after as part of the LaGuardia Airport Access Alternatives Analysis.

Bx41 SBS service would use a new off-street stop at the Gun Hill Intermodal Terminal to improve the connection to the subway.