C15orf52

Chromosome 15 open reading frame 52 is a human protein encoded by the C15orf52 gene, its function is poorly understood.

C15orf52 is a gene located on the reverse strand of chromosome 15 in the species Homo sapiens at locus 15q15.1.

[1] The gene contains 12 distinct introns, 11 exons, produces 7 different mRNAs, and 6 alternatively spliced variants.

[10] N-terminal acetylations, C-glycosylations, glycations, leucine rich nuclear export signals, sumoylation, and PEST motifs were all predicted across orthologs for this protein.

[12] THOC1 is a component of the THO subcomplex of the TREX complex that is thought to couple mRNA transcription, processing and nuclear export.

SUZ12 is also a polycomb group protein and part of a complex that methylates lysines of histones and also is involved with repression of genes.

Origin of cDNAs of C15orf52 shows that the gene is expressed in numerous locations such as primary and secondary digestive organs (pancreas, stomach, liver, etc.

), nervous system (brain, retina, lens), skin, reproductive organs, bones, and many other tissues suggesting a fairly nonspecialized function.

[3] However, C15orf52 protein is relatively over-expressed in the colon, peripheral blood mononuclear cells, testis, and rectum.