12898927883ENSG00000183597ENSMUSG00000013539Q6ICL3P54797NM_001283179NM_001283186NM_001283199NM_001283215NM_001283235NM_001283248NM_152906NM_001322141NM_001322142NM_001322143NM_001322144NM_001322145NM_001322146NM_001322147NM_001322148NM_001322149NM_001322150NM_001322153NM_001322155NM_001322160NM_001322163NM_001322166NM_001322167NM_001322169NM_001322171NM_001322172NM_001322173NM_001322174NM_001322175NM_138583NP_001270108NP_001270115NP_001270128NP_001270144NP_001270164NP_001270177NP_001309070NP_001309071NP_001309072NP_001309073NP_001309074NP_001309075NP_001309076NP_001309077NP_001309078NP_001309079NP_001309082NP_001309084NP_001309089NP_001309092NP_001309095NP_001309096NP_001309098NP_001309100NP_001309101NP_001309102NP_001309103NP_001309104NP_690870n/aTransport and golgi organization 2 homolog (TANGO2) also known as chromosome 22 open reading frame 25 (C22orf25) is a protein that in humans is encoded by the TANGO2 gene.

This domain is found among distantly related species from the six kingdoms:[4] Eubacteria, Archaebacteria, Protista, Fungi, Plantae, and Animalia and is known to be involved in Golgi organization and protein secretion.

In Caenorhabditis elegans, the snt-1 gene (C22orf25 homologue) was expressed in the nerve ring, ventral and dorsal cord processes, sites of neuromuscular junctions, and in neurons.

Post translational modifications of the C22orf25 gene that are evolutionarily conserved in the Animalia and Plantae kingdoms as well as the Canarypox Virus include glycosylation (C-mannosylation),[23] glycation,[24] phosphorylation (kinase specific),[25] and palmitoylation.

[34] Mutations in the TANGO2 gene may cause defects in mitochondrial β-oxidation[35] and increased endoplasmic reticulum stress and a reduction in Golgi volume density.

[36] These mutations results in early onset hypoglycemia, hyperammonemia, rhabdomyolysis, cardiac arrhythmias, and encephalopathy that later develops into cognitive impairment.