[2] The most common symptoms of CAEBV include:[1][3][4][5] Complications include:[1][3][5] It arises from the cells that constitute the immune system, most often the T-cells and NK cells in Asians/South Americans and the B-cells in the other racial groups.
[1] Various cytokine anomalies have been reported in people with CAEBV, examples include:[5][7] There is also evidence supporting a role for TGF-β in the disease.
[7] Those that develop the haemophagocytic syndrome often exhibit an abnormally high amount of IL-1β and IFN-γ.
[8] The only known cure for CAEBV is allogenic haematopoietic stem cell transplant (HSCT), with all other treatment options (rituximab, cytotoxic chemotherapy and immunosuppressive therapy) being nothing more than stopgaps.
[8] Factors indicative of a poor prognosis include: thrombocytopenia, late onset of the disease (age ≥ 8 years) and T cell involvement.