If only two parameters from the complete blood count are low, the term bicytopenia can be used.
Along with pancytopenia, HLH is characterized by fever, splenomegaly, and hemophagocytosis in bone marrow, liver, or lymph nodes.
[4] Pancytopenia usually requires a bone marrow biopsy in order to distinguish among different causes.
[6] In this selected cases even with severe anemia blood product transfusions can be avoided and vitamin B12 treatment itself suffice.
[7] In other situations like acute leukemia, Myelodysplastic syndrome, aplastic anemia etc.