[5][6] Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases.

The heterodimer interface is predominantly found between domain IV and the small subunit, which is also a calmodulin-like calcium-binding domain.

This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region.

Multiple alternative transcript variants encoding different isoforms have been described for this gene.

[7] This article on a gene on human chromosome 2 is a stub.