n/an/an/an/anan/an/an/an/an/aCalpain small subunit 1 (CSS1) is a protein that in humans is encoded by the CAPNS1 gene.
[1][2][3] Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases.
Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress.
[3] This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy.
[3] 'Elevated expression of CAPNS1 has been found to be associated with progression of various cancers such as hepatocellular and renal carcinoma.