[5][6][7] The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices.

It participates in signaling through highly specific protein-protein homophilic interactions.

CARDs induce nuclear factor kappa-B (NF-κB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex.

Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.

This article on a gene on human chromosome 22 is a stub.