[5][6][7] The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane.

The homotypic interaction with BCL10 is believed to be prevented by the linker region of CARD14, when in an inactive state.

It has been suggested that a mutation in the gene plus an environmental trigger were enough to elicit plaque psoriasis.

[9][10] These rare, but highly penetrant, mutations were found to disrupt an auto-inhibited state of CARD14, which leads to the binding of BCL10 and the activation of NF-κB.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.