TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB.

[6] It is a positive regulator of apoptosis,[7] and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

[citation needed] Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors.

[6][7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.