2NMS146722246746ENSG00000186074ENSMUSG00000047798Q8TDQ1Q6SJQ7NM_001289087NM_139018NM_001169153NM_145634NM_001347648NP_001276016NP_620587NP_001162624NP_001334577NP_663609CMRF35-like molecule 1, also known as CD300lf, is a protein that in humans is encoded by the CD300LF gene.

CD300lf is a membrane glycoprotein that contains an immunoglobulin domain and is expressed by myeloid and mast cells[7] of humans and other mammals.

The protein functions in immunoregulation[8] but might also have a role in norovirus infections.

CD300lf has been shown to function as the primary receptor for murine norovirus in mice,[9][10] Human norovirus does not use the same receptor in viral entry.

[11] Human and murine CD300lf proteins have about 59% identity in their immunoglobulin domains, with most of that variation occurring in parts of the protein called CDR3 and the CC’loop.