2KW6809913445ENSG00000111328ENSMUSG00000029394O14519O35207NM_001270433NM_001270434NM_004642NM_013812NP_001257362NP_001257363NP_004633NP_038840Cyclin-dependent kinase 2-associated protein 1 is an enzyme that in humans is encoded by the CDK2AP1 gene.

[5][6][7] The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis.

This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle.

A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.

[8] It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.