It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family.

It contains a helix-loop-helix DNA binding motif at the N-terminus and a dimerization domain at the C-terminus.

This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes.

It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.