It has been found in high levels in the bone marrow of patients with a negative prognosis of acute myeloid leukemia and an abnormal karyotype.

[9] There are no clear paralogs in humans, but the gene has homologues widely conserved among animals, fungi, and algae.

This domain is primarily found in homologues of CFAP298, but also in other uncharacterized proteins,[14] and it contains the majority of the sites that are modified after translation.

The protein is predicted to consist mostly of alpha helices and lack beta strands.

[20] A study in zebrafish has shown CFAP298 is found in high concentrations in the Kupffer vesicles, and is intracellularly localized to the basal body of the cilia.