The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults age 0–21.

The hospital expanded early into its history with a 50-bed expansion taking place in 1919 with support from the Scottish Rite Freemasons of the Supreme Council, Southern Jurisdiction.

[9] By 1969, the original Scottish Rite building had been in operation for 50 years, and the facilities needed expansion and updates.

[10][11] In 1983 Scottish Rite Children's Hospital again expanded with the addition of 96 patient beds and a new clinical outpatient building.

To achieve its second Magnet designation, Scottish Rite had to continue demonstrating an exceptional practice environment for nurses and meeting high standards for patient experience.