Christus St. Vincent Regional Medical Center is a general hospital located in Santa Fe, New Mexico, United States.

The hospital is the oldest in the State of New Mexico, since being established in the downtown plaza before it was moved in 1977 to developing St. Michaels Drive.

It is one of two Level III Trauma Center in Northern New Mexico.

A religious institution until it became public in 1973, it joined the Christus Health network of Catholic hospitals in 2008.

In 2018, the culmination of a $44 million expansion is resulting in all-private patient rooms, which was the most-requested feature in a 2014 survey of the local area population.