160364232413ENSG00000172322ENSMUSG00000053063Q5QGZ9Q504P2NM_001207010NM_001300730NM_138337NM_201623NM_201625NM_177686NP_001193939NP_001287659NP_612210NP_963917NP_808354C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.

Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response.

The protein encoded by this gene is a negative regulator of granulocyte and monocyte function.

[6] Murine MICL is expressed as dimer on granulocytes, monocytes but also on B lymphocytes and can be also found on NK cells surface in bone marrow.

CLL-1 is also expressed on the surface of leukemic stem cells (LSC), which possesses the ability to indefinitely self-renew, produce plenty of leukemic cells and are associated with leukemia relapses.