In humans, it is encoded by the CMTM2 gene located in band 22 on the long (i.e. "q") arm of chromosome 16.

[7] CMTM2 protein levels were also lower in the hepatocellular carcinoma tissues that had a more aggressive pathology and therefore a possible poorer prognosis.

[8] Finally, the forced overexpression of CMTM2 protein in cultured hepatocellular tumor cells inhibited their invasiveness and migration.

[8] These findings suggest that CMTM2 protein suppresses the development and/or progression of hepatocellular carcinoma and therefore that the CMTM2 gene acts as a tumor suppressor in this cancer.

Further studies are needed to confirm these findings and determine if CMTM2 protein can serve as a marker for the severity of these three cancers and/or as a therapeutic target for treating them.