Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3% of the total DNA in cells.

The following are some of the gene count estimates of human chromosome 16.

Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction).

So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.

[4] The following is a partial list of genes on human chromosome 16.