It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling.

[5] It is the mammalian homolog of the Drosophila gene Cnk, which is known to bind Raf, and is implicated in ras signalling.

It has been shown that CNKSR2 is also a Raf binding protein, and is assumed to function in bringing together the Ras signalling complex at the post synaptic density.

Proteomic work done on binding partners of Ksr2 suggests that the CNKSR2/KSR2 complex may play a role in mediating crosstalk between the MAPK, Pi3K and insulin pathways.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.