The Cabinet of the Prime Minister is composed of multiple departments directly responsible to the Premier and coordinated by the Chief of Staff.

The Royal Decree was very short and it only said that the Cabinet was and advisory body to the Prime Minister with the functions that the Primer would like to grant to it.

Prime minister José Luis Rodrígez Zapatero didn't made many changes, with the exception of the creation of the Economic Office.

With Rajoy the Cabinet Office also received responsibilities over the Government communication policy by assuming the Secretariat of State for Press.

The Office of the Deputy Chief of Staff is composed by the Deputy Chief of Staff and four departments: Led by the Secretary-General of the Prime Minister's Office, the General Secretariat duties are: The General Secretariat is composed by three departments: Because they share assistance duties to the Prime Minister, both Secretary-General and Undersecretary of the Presidency coordinate together their work.

It is composed of three departments: It is the responsibility of the General Secretariat for Foreign Affairs, within the scope of the functions assigned to the Prime Minister's Cabinet, to provide advice, support and assistance to the Prime Minister in matters related to its international activity, foreign relations and multilateral and global affairs.