[2] Cabuyao station was opened on 7 November 1908 on the South Main Line.

Cabuyao station is part of the Alabang–Calamba segment that was closed starting in 2023 to prepare for the construction of the Clark–Calamba Railway.

Major landmarks nearby include the city public market, the city public schools, St. Polycarp Parish, Savemore Market, and Asian Institute of Technology, Sciences and the Arts.

Cabuyao station is primarily accessed by foot and served by tricycles.

Jeepneys ply on the poblacion's main street a few hundred meters away, connecting commuters to other towns in Laguna from Calamba, Biñan, to San Pedro.