The cadmium resistance (CadD) protein family (TC# 2.A.77) belongs to the Lysine exporter (LysE) superfamily.
Two are close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance, a fourth has been reported to function in quaternary ammonium cation export, and the fourth is a distant open reading frame (ORF) in Staphylococcus aureus.
These three families, which are included in the LysE superfamily, all consist of proteins of similar sizes (about 200 residues) and topologies (6 putative transmembrane α-helical segments; 5 experimentally determined TMSs).
As of 25 February 2016, this article is derived in whole or in part from Transporter Classification Database, authored by Saier Lab Bioinformatics.
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