[2] They provide ionic homeostasis, play a role in cell envelope assembly, and protect from excessive concentrations of heavy metals in cytoplasm.
The superfamily was named based on the early discovery of the LysE carrier protein of Corynebacterium glutamicum.
Thus, LysE family members are found widely distributed in Gram-negative and Gram-positive bacteria.
PhoA fusion analyses of LysE of C. glutamicum provided evidence for a 5 transmembrane α-helical spanner (TMS) typology with the N-terminus inside and the C-terminus outside.
The E. coli ArgO homologue (TC# 2.A.75.1.2) effluxes arginine and possibly lysine and canavanine as well.