Within 25 years of founding his brewery, Cain had established 200 pubs, including the Philharmonic Dining Rooms, the Vines and the Central Commercial Hotel, which are currently listed as being of architectural merit.

Five years later Boddingtons opted to concentrate on pub ownership and sold all its breweries to Whitbread, at which point the Stanhope Street site was closed.

Viewing Cains as a route into the UK market, Faxe Bryggeri A/S (now Royal Unibrew) then acquired the company and invested in its ales and local pubs.

Unlike its larger competitor Carlsberg, Faxe failed to crack the UK market and put Cains up for sale in 2002.

[5] In 2013, Cains began a redevelopment of the site for leisure and housing with a small craft brewery to continue production of its ales.

The million square foot site would have included a 94-bedroom hotel, cinema, bistro bar, restaurants and an open-plan retail hall for artisan food producers.

It was open four times a week and operated by Baltic Markets, offering food, drink, entertainment and live events.

[12] In April 2023, brewing stopped due a royalties dispute between the owners of the Cains brand (Dusanj Brothers) and the micro brewery operator, Mikhail Leisure.