Cairo /ˈkɛəroʊ/ is a town in Greene County, New York, United States.

The first European-American settler arrived around 1772, but many new families moved in after the American Revolution.

As of the census[9] of 2000, there were 6,355 people, 2,579 households, and 1,709 families residing in the town.

28.4% of all households were made up of individuals, and 14.0% had someone living alone who was 65 years of age or older.

Fire Co. Inc. Cairo Ambulance responds to medical emergencies in the town.