Caleicine is a unique sesquiterpene compound found exclusively in Calea ternifolia, a Mexican flowering plant known for its potential psychoactive properties.

[1] This compound has garnered interest in the field of ethnopharmacology and natural product chemistry due to its putative role as a prodrug of eugenol, a potent GABA positive modulator.

Caleicine is a sesquiterpene that has a phenylpropanoid moiety bonded to junenol[2] In an investigation, lab mice were administered with an aqueous solution of Calea Ternifolia in doses of 200, 400 and 800 mg and made to undergo a forced swim test.

[5][6] Calea ternifolias negative side effects, nausea, vomiting and delirium based hallucinations,[7] are the same that of Eugenol[6] and other GABAergic compounds.

The properties of GABA positive modulating substances typically are anxiolytic, anticonvulsant, oneirogenic, sedative, hypnotic, euphoriant, and muscle relaxant effects.