Mississippi Highway 9 runs through the center of the town, leading north 6 miles (10 km) to Pittsboro, the county seat, and 10 miles (16 km) north to Bruce.

As of the 2020 United States Census, there were 1,533 people, 709 households, and 436 families residing in the town.

26.4% of all households were made up of individuals, and 15.6% had someone living alone who was 65 years of age or older.

Calhoun City High School's athletic teams are known as the Wildcats.

In 1968, Calhoun Academy was formed as a segregation academy by white parents seeking to avoid sending their children to racially integrated public schools.