Slate Springs is a village in Calhoun County, Mississippi, United States.

According to the United States Census Bureau, the village has a total area of 1.4 square miles (3.7 km2), all land.

28.6% of all households were made up of individuals, and 16.3% had someone living alone who was 65 years of age or older.

There were 26.3% of families and 27.3% of the population living below the poverty line, including 36.2% of under eighteens and 58.3% of those over 64.

Slate Springs is served by the Calhoun County School District.