Pittsboro is a village in Calhoun County, Mississippi, United States.

According to the United States Census Bureau, the village has a total area of 0.97 square miles (2.5 km2), all land.

There were 83 housing units at an average density of 83.8 per square mile (32.4/km2).

30.0% of all households were made up of individuals, and 15.7% had someone living alone who was 65 years of age or older.

Pittsboro is served by the Calhoun County School District.