Calhoun County High School is a public secondary school in St. Matthews, South Carolina, United States.

The campus has a pasture with the new K–8 school in front of it on Saints Avenue.

The school's sports teams, known as the Saints, compete in the South Carolina High School League Class AA, Region V. They field teams in baseball, basketball, football, softball, track, and volleyball.

[citation needed] State championship titles held by the school's teams include: The boys' basketball team holds the state record for consecutive wins, at 78.

This South Carolina school-related article is a stub.