For the next decade, she toured with, and directed portions of, Alice Cooper's live shows, specializing in violent black comedy routines.

Her film credits include minor roles in The Curse of El Charro (2005), Rolling (2007), a deleted scene in Halloween (2007), Dakota Skye (2008), Suck (2009), and an uncredited scene in Hall Pass (2011), and co-starring roles in Thirty Proof Coil (2010), 13/13/13 (2013), Welcome to Hell (2018), and the short film Fire Fucking Fire (2024).

Her television credits include the character Lila Black in Bloomers (2011–2018) and guest starring as Jane Miller in a 2016 episode of Hawaii Five-0.

[9][10] While attending Arcadia High, she belonged to a dance company and professionally performed and competed at the national level in classical ballet, jazz, acrobatics, and tap.

At age 18, she was hired by Alice to perform multiple roles in and provide choreography and design costumes for his Brutal Planet tour.

'"[15] A routine she performed in 2000, dressed as the nurse, involved Alice grabbing her by the neck and slamming her into the hatch of an overturned vehicle.

[18] Her tour with Brutal Planet at first intimidated her as she, like her mother before, was the only woman not only among the band but among the merchandise staff, catering, and drivers, and she was cautious of overstepping.

[12] When Chuck Garric joined Alice Cooper's live band as a bassist in 2002, he and Calico immediately bonded creatively and enthusiastically shared and discussed performance ideas with each other.

[21][22] On the Dirty Diamonds tour in 2005, Calico replaced the Britney character with a mock Paris Hilton who has her throat ripped out by a chihuahua, sending fake blood spurting into the audience.

[23][24][13] Another routine as Hilton involved her attempting to stab Alice only for him to deflect the blow, grab her by the hair, and drag her offstage.

[13] She said in 2011 that since childhood she always tried to make people laugh, and "For all the years that I toured with my dad, the harder I could fall on my face, or the bigger reaction I could get, it didn't matter what language you spoke it was funny.

"[28] The members of the show also liked to pull pranks, such as duct taping the guitarist of the opening act and throwing him out of the venue, hiding Calico's skirt so she had to come on stage in her underwear, or one time, the final show of Alice Cooper touring with Scorpions, when Alice and her conspired to have the male members of his band dress in lingerie and replace the dancing girls on the Scorpions' set.

[30] In 2017, Calico performed as the nurse character, getting roughed up during "Only Women Bleed" but coming back to torment Alice while he was straitjacketed singing "The Ballad of Dwight Fry".

[14][33] Cooper portrayed Heather in Dakota Skye (2008),[34] a barmaid in the horror film Suck (2009), and co-starred as the "Woman" character in Thirty Proof Coil (2010).

[8] When she left the Alice Cooper tours in 2011, at the advice of local actors she enrolled in master classes taught by Ivana Chubbuck.

After taking the course, at Chubbuck's recommendation, she auditioned, successfully, for the improv comedy groups The Groundlings and Upright Citizens Brigade Theatre.

[37] In 2011, she landed a starring role in the TV series Bloomers (2011–2018) as the recurring character Lila Black[38][39] and made an uncredited cameo in Hall Pass (2011).

"[19] During their European tour, they developed a signature sound and visual style, melding heavy metal with a gruesome stage show, Cooper dressing in fishnet, chains, and leather, and often brandishing some form of weapon,[19] including a Louisville slugger with nails through it and a CO2 gun.

[47] Calico said that when she focused her career on film and television work, she missed performing live, and joining Beasto Blanco allowed her spontaneity and opportunities to push boundaries.

[50] A reviewer of a concert by the band in 2022 compared the aesthetic of the group to Mad Max: Fury Road with the stagecraft of Alice Cooper.

[49] She said in a 2018 interview that when she first started developing her character (which in boots stands about 7 feet tall), she assumed that men would respond well to her, but she also then had women coming up to her afterwards to say how her performances are empowering for them.

She states that her parents played a lot of classic artists such as Laura Nyro and Burt Bacharach, contemporary acts such as Zodiac Mindwarp and Guns ‘N Roses, as well as Elvis Presley and The Beatles.

[8] In 2020, she mentioned listening to genres outside of rock – classical, electronic, heavy blues – to incorporate into her music with Beasto Blanco.

[49] A review of Live Fast Die Loud, the first album of Beasto Blanco, compared the musical style of the group to Alice Cooper and White Zombie.